Search on: OPHTHALMOPLEGIA, PROGRESSIVE SUPRANUCLEAR 
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Descriptor English:   Supranuclear Palsy, Progressive 
Descriptor Spanish:   Parálisis Supranuclear Progresiva 
Descriptor Portuguese:   Paralisia Supranuclear Progressiva 
Synonyms English:   Steele-Richardson-Olszewski Syndrome
Ophthalmoplegia, Progressive Supranuclear
Progressive Supranuclear Ophthalmoplegia  
Tree Number:   C10.228.140.079.882
C10.228.662.700
C10.292.562.750.500
C10.574.945.500
C10.597.622.447.690
C11.590.472.500
C23.888.592.636.447.690
Definition English:   A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7) 
History Note English:   1987 
Allowable Qualifiers English:  
blood cerebrospinal fluid
chemically induced classification
congenital complications
diet therapy diagnosis
drug therapy economics
ethnology embryology
enzymology epidemiology
etiology genetics
history immunology
metabolism microbiology
mortality nursing
pathology prevention & control
physiopathology parasitology
psychology radiography
rehabilitation radionuclide imaging
radiotherapy surgery
therapy urine
ultrasonography veterinary
virology  
Record Number:   19356 
Unique Identifier:   D013494 

Occurrence in VHL: 		 

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